Rhinovirus infection in young children is associated with elevated airway TSLP levels.
نویسندگان
چکیده
respiratory utopia or common sense? Thorax 2013; 68: 691–694. 4 Han MK, Agusti A, Calverley PM, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med 2010; 182: 598–604. 5 Celli BR, Cote CG, Marı́n JM, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 1005–1012. 6 Soler-Cataluña JJ, Martı́nez-Garcı́a MA, Sánchez L, et al. Severe exacerbations and BODE index: two independent risk factors for death in male COPD patients. Respir Med 2009; 103: 692–699. 7 Agustı́ A, Calverley PMA, Celli B, et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res 2010; 11: 122. 8 Jones PW, Harding G, Berry P, et al. Development and first validation of the COPD Assessment Test. Eur Respir J 2009; 34: 648–654. 9 Van der Molen T, Willemse BWM, Schokker S, et al. Development, validity and responsiveness of the clinical COPD questionnaire. Health Qual Life Outcomes 2003; 1: 13. 10 Agustı́ A, Soler JJ, Molina J, et al. Is the CAT questionnaire sensitive to changes in health status in patients with severe COPD exacerbations? COPD 2012; 9: 492–498. 11 Miravitlles M, Garcı́a-Sidro P, Fernández-Nistal A, et al. Course of COPD assessment test (CAT) and clinical COPD questionnaire (CCQ) scores during recovery from exacerbations of chronic obstructive pulmonary disease. Health Qual Life Outcomes 2013; 11: 147. 12 Kon SSC, Canavan JL, Jones SE, et al. Minimum clinically important difference for the COPD Assessment Test: a prospective analysis. Lancet Respir Med 2014; 2: 195–203. 13 Kocks JWH, Tuinenga MG, Uil SM, et al. Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire. Respir Res 2006; 7: 62. 14 Miravitlles M, Soler-Cataluña JJ, Calle M, et al. Spanish COPD guidelines (GesEPOC). Pharmacological treatment of stable COPD. Arch Bronconeumol 2012; 48: 247–257.
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 44 4 شماره
صفحات -
تاریخ انتشار 2014